Friday, February 8, 2013

Google acquires e-commerce company Channel Intelligence for $125 million

Google just acquired the coupon-focused company Incentive Targeting and retail locker startup BufferBox in November, and it's now further bolstered its e-commerce offerings with an acquisition of Channel Intelligence for $125 million. That company is part of the ICG Group, and offers a variety of marketing and shopping services (primarily concerned with boosting sales) to other companies and online retailers, including Staples and Best Buy. It's also partnered with Google itself in recent years on Google Shopping. Barring any unforeseen hiccups, the company expects the acquisition to close sometime in the first quarter of this year.

Update: We've now also gotten this statement on the acquisition from a Google spokesperson: "We want to help consumers save time and money by improving the online shopping experience. We think Channel Intelligence will help create a better shopping experience for users and help merchants increase sales across the web."

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Via: TechCrunch

Source: Channel Intelligence

Source: http://www.engadget.com/2013/02/06/google-acquires-e-commerce-company-channel-intelligence-for-125/

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Thursday, February 7, 2013

Rand Paul To Call For 'Reluctant' Foreign Policy - Business Insider

rand paul israelKentucky Senator Rand Paul will call for a more moderate, "restrained" approach to U.S. foreign policy Wednesday, delivering a highly-anticipated Heritage Foundation speech on "restoring the Founders' vision of foreign policy."?

The speech, which has been billed as a foreign policy coming-out party for Paul, marks the Kentucky libertarian's latest attempt to bridge the divide with foreign policy hawks in his party as he prepares for a possible presidential run in 2016.

Paul has made several public overtures to neoconservative Republicans in recent weeks, including a highly-publicized trip to Israel?last month and his verbal attacks on Secretary of State Hillary Clinton during her Senate hearing on Benghazi.?

In his remarks Wednesday, Paul will continue to attempt this detente, framing libertarian ideas of non-isolationism within the context of hawkish rhetoric about the looming threat of radical Islam.?

But Paul will stop short of going full neocon, calling instead for a "middle path" along the lines of the Cold War strategy of containment.?

"What the United States needs now is a policy that finds a middle path," Paul will say, according to advance excerpts of his remarks. "A policy that is not rash or reckless. A foreign policy that is reluctant, restrained by Constitutional checks and balances but does not appease. A foreign policy that recognizes the danger of radical Islam but also the inherent weaknesses of radical Islam. A foreign policy that recognizes the danger of bombing countries on what they might someday do...A policy that understands the 'distinction between vital and peripheral interests.'"

What that "middle path" would look like, however, remains unclear. Paul will stop short of offering any specific foreign policy proposals, and avoid answering questions about his own vision for the U.S. role in the world.?

Instead, his speech will focus on the process by which Congress can restrain executive military action, and thus open up space for the type of foreign policies that Paul advocates.?

"I?d argue that a more restrained foreign policy is the true conservative foreign policy, as it includes two basic tenets of true conservatism: respect for the constitution, and fiscal discipline," Paul will say. "I am convinced that what we need is a foreign policy that works within these two constraints, a foreign policy that works within the confines of the Constitution the realities of our fiscal crisis. Today in Congress there is no such nuance, no such moderation of dollars or executive power."

Now here's why Rand Paul called his trip to Israel the 'PLAGUE TOUR' >?

Source: http://www.businessinsider.com/rand-paul-foreign-policy-speech-2013-2

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Attack ads launched against Sen. McConnell on guns

Republican Mitch McConnell knows that as Republican Senate Minority Leader and a symbol of the party establishment, he's the target of conservatives, tea partyers and others on the right (which he discussed in his exclusive interview with Yahoo! last week).

But now some progressives have him in their sights, believing the Kentucky Republican's opposition to gun reform offers Democrats a foothold in McConnell's 2014 re-election race. Case in point: The Progressive Change Campaign Committee launched an ad campaign on Tuesday attacking McConnell's gun stance.

"Sen. Mitch McConnell has taken thousands of dollars from gun manufacturers, and he opposes common-sense reforms. Sen. McConnell, whose side are you on?" the ad's narrator, Kentucky voter Rodney Kendrick, asks in the ad as he holds his grandson on his lap.

The ad launched with a $27,700 initial buy on broadcast and cable in Louisville and Lexington and on cable in Washington, D.C., according to the committee.

The PCCC said data it commissioned from the Democratic firm Public Policy Polling suggests Kentucky voters back some of the reforms for which McConnell has not issued public support, including universal background checks and an assault weapons ban.

Eighty-two percent of likely Kentucky voters surveyed by the firm stated support for universal background checks. Thirteen percent were opposed. That survey's margin of error was plus or minus 3.8 percentage points.

The firm also asked about an assault weapons ban and found wide support.

But McConnell campaign manager Jesse Benton on Tuesday dismissed the ad and the group behind it, saying in a statement: "Sen. McConnell fully anticipated that protecting Kentucky from President Obama's gun-control agenda would result in a flurry of attack ads from left-wing groups. It's not a secret to Kentuckians that Sen. McConnell is a stalwart supporter of their Second Amendment rights and George Soros-funded commercials aren't going to change that."

Actress Ashley Judd has expressed interest in running for the Democratic nomination for the Kentucky U.S. Senate seat, but it remains unclear if she is serious about pursuing a campaign.

Source: http://news.yahoo.com/blogs/ticket/progressives-launch-attack-ads-against-mcconnell-guns-144320664--election.html

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Monday, February 4, 2013

Milestone of cancer research: Arresting cancers rather than killing them

Feb. 1, 2013 ? The research team of Prof. Dr. Martin R?cken from the Department of Dermatology of the University Medical Center T?bingen has shown for the first time that the immune system is able to drive tumours and tumour cells into a form of permanent dormancy (1). The resulting growth arrest allows tumour control in the absence of cancer cell destruction. This permanent dormancy -- scientifically known as senescence (2, 3) -- may persist for the whole life of the organism. Thus, immunotherapy can prevent tumour development without destroying the cells (1, 4).

Prof. Martin R?cken, Director of the Department of Dermatology of the University Medical Center T?bingen, outlines the current state of tumour therapy as follows: "About 50 years ago the former President of the United States of America Richard Nixon declared the "War on cancer." Strong financial and logistic efforts were undertaken and thought to overcome this devastating disease in relatively short time. At this time, researchers and clinicians learned to use chemotherapeutics or natural killer cells to directly attack the tumour cells and to destroy cancers including their environment. This led to several very important, partly brilliant achievements in the understanding of tumour development and to improved cancer diagnostics. What's more, the treatment of several different cancers was markedly improved by new and innovative operation techniques, radiation, chemo- and immunotherapy. However, the main goal, ie. the decisive victory on cancer, remained absent." "[For some time]," Prof. R?cken explains further, "doubts were raised about the strategy of the "War on cancer" which exclusively focussed on cancer destruction, as for example published in an essay in the journal The Lancet and other recent publications (5, 6, 7)."

Importantly, the work of the R?cken group revealed that immune responses also drive tumours of human origin into senescence. The human body apparently defends itself from cancer by inducing the senescence program in tumour cells thereby inhibiting tumour growth (1).

In this line, two well known signalling molecules of cancer therapy and immunology of infectious diseases move again in the center of attention: the interferons and tumor necrosis factor. Repeatedly, a bulk of researchers and clinicians tried to use these molecules and other techniques to destroy the tumour cells and their supplying blood vessels, and so did the scientists from T?bingen. Surprisingly, however, the R?cken group found that a combination of both signalling molecules, interferon and tumor necrosis factor, stopped the tumour growth in vivo without any signs of tumour or tissue destruction.

In animal experiments, the efficacy of immunotherapy-induced senescence proved to be much better than any other therapy based on "cancer destruction" (4). Most importantly, the common action of both signalling molecules, interferon and tumor necrosis factor, also stopped the growth of human tumours (1).

In the course of a natural immune response, the research team even detected senescence induction in regressing malignant tumours of cancer patients . Seven years ago, it was shown in principle that cancer cells can be shifted towards permanent dormancy or senescence (2, 3). Those theoretical insights were now successfully transferred into a therapeutic approach, here an immunotherapeutic regimen (1, 4).

The new therapeutic option will enable clinicians to approach their goal of a life-prolonging, mainly adverse effect-free cancer therapy. "It is very likely that we can't win the "War on cancer" by exclusive military means.," Prof. R?cken resumes. "Instead, it will be an important milestone to restore the bodies? immune control of malignant tumours."

Notes:

1. Braum?ller et al. M. T-helper-1-cell cytokines drive cancer into senescence. Nature, in press (2013).

2. Michaloglou, C. et al. BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 436, 720-724 (2005).

3. Braig, M. et al. Oncogene-induced senescence as an initial barrier in lymphoma development. Nature 436, 660-665 (2005).

4. M?ller-Hermelink, N. et al. TNFR1 signaling and IFN-gamma signaling determine whether T cells induce tumor dormancy or promote multistage carcinogenesis. Cancer Cell 13, 507-518 (2008).

5. Sporn, MB. The war on cancer. The Lancet 347, 1377-1381 (1996).

6. Gatenby, RA. A change of strategy in the war on cancer. Nature 459, 508-509 (2009).

7. R?cken, M. Early tumor dissemination, but late metastasis: insights into tumor dormancy. J. Clin. Invest. 120, 1800-1803 (2010).

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The above story is reprinted from materials provided by Universitaet T?bingen, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Heidi Braum?ller, Thomas Wieder, Ellen Brenner, Sonja A?mann, Matthias Hahn, Mohammed Alkhaled, Karin Schilbach, Frank Essmann, Manfred Kneilling, Christoph Griessinger, Felicia Ranta, Susanne Ullrich, Ralph Mocikat, Kilian Braungart, Tarun Mehra, Birgit Fehrenbacher, Julia Berdel, Heike Niessner, Friedegund Meier, Maries van den Broek, Hans-Ulrich H?ring, Rupert Handgretinger, Leticia Quintanilla-Martinez, Falko Fend, Marina Pesic, J?rgen Bauer, Lars Zender, Martin Schaller, Klaus Schulze-Osthoff, Martin R?cken. T-helper-1-cell cytokines drive cancer into senescence. Nature, 2013; DOI: 10.1038/nature11824

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/cxjxvUM8tbk/130203212411.htm

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Wall Street fairy tale? Bull market may hit a snag

Wall Street's current jubilant narrative is that a rush into stocks by small investors has sparked a "great rotation" out of bonds and into equities that will power the bull market to new heights.

That sounds good, but there's a snag: The evidence for this is a few weeks of bullish fund flows that are hardly unusual for January.

Late-stage bull markets are typically marked by an influx of small investors coming late to the party - such as when your waiter starts giving you stock tips. For that to happen you need a good story. The "great rotation," with its monumental tone, is the perfect narrative to make you feel like you're missing out.

Even if something approaching a "great rotation" has begun, it is not necessarily bullish for markets. Those who think they are coming early to the party may actually be arriving late.

The stock market may have packed much of its fun for the year into one exhilarating January.

The market charged to its best start in decades even though the U.S. economy and corporate profits haven't broken out of a three-year pattern of slow, steady improvement despite record-low interest rates and billions of dollars of stimulus and tax cuts.

This steady growth will likely make for a good year for stocks, but January may account for much of the year's rise, analysts think.

"We thought this was going to be a good year for equities, we just didn't think we'd get it all in the first month," says Barry Knapp, head of U.S. equity strategy at Barclays Capital. "I'd love for the market to keep going up but when I look forward I see a lot of headwinds."

Investors pumped $20.7 billion into stocks in the first four weeks of the year, the strongest four-week run since April 2000, according to Lipper. But that pales in comparison with the $410 billion yanked from those funds since the start of 2008.

"I'm not sure you want to take a couple of weeks and extrapolate it into whatever trend you want," said Tobias Levkovich, chief U.S. equity strategist at Citigroup. "We have had instances where equity flows have picked up in the last two, three, four years when markets have picked up. They've generally not been signals of a continuation of that trend."

The S&P 500 rose 5 percent in January, its best month since October 2011 and its best January since 1997, driving speculation that retail investors were flooding back into the stock market.

Heading into another busy week of earnings, the equity market is knocking on the door of all-time highs due to positive sentiment in stocks, and that can't be ignored entirely. The Standard & Poor's 500 Index <.SPX> ended the week about 4 percent from an all-time high touched in October 2007.

Next week will bring results from insurers Allstate and The Hartford , as well as from Walt Disney , Coca-Cola Enterprises and Visa .

But a comparison of flows in January, a seasonal strong month for the stock market, shows that this January, while strong, is not that unusual. In January 2011 investors moved $23.9 billion into stock funds and $28.6 billion in 2006, but neither foreshadowed massive inflows the rest of that year. Furthermore, in 2006 the market gained more than 13 percent while in 2011 it was flat.

Strong inflows in January can happen for a number of reasons. There were a lot of special dividends issued in December that need reinvesting, and some of the funds raised in December tax-selling also find their way back into the market.

During the height of the tech bubble in 2000, when retail investors were really embracing stocks, a staggering $42.7 billion flowed into equities in January of that year, double the amount that flowed in this January. That didn't end well, as stocks peaked in March of that year before dropping over the next two-plus years.

Mom and Pop still wary
Arguing against a 'great rotation' is not necessarily a bearish argument against stocks. The stock market has done well since the crisis. Despite the huge outflows, the S&P 500 has risen more than 120 percent since March 2009 on a slowly improving economy and corporate earnings.

This earnings season, a majority of S&P 500 companies are beating earnings forecast. That's also the case for revenue, which is a departure from the previous two reporting periods where less than 50 percent of companies beat revenue expectations, according to Thomson Reuters data.

Meanwhile, those on the front lines say mom and pop investors are still wary of equities after the financial crisis.

"A lot of people I talk to are very reluctant to make an emotional commitment to the stock market and regardless of income activity in January, I think that's still the case," said David Joy, chief market strategist at Columbia Management Advisors in Boston, where he helps oversee $571 billion.

Joy, speaking from a conference in Phoenix, says most of the people asking him about the "great rotation" are fund management industry insiders who are interested in the extra business a flood of stock investors would bring.

He also pointed out that flows into bond funds were positive in the month of January, hardly an indication of a rotation.

Citi's Levkovich also argues that bond investors are unlikely to give up a 30-year rally in bonds so quickly. He said stocks only began to see consistent outflows 26 months after the tech bubble burst in March 2000. By that reading it could be another year before a serious rotation begins.

On top of that, substantial flows continue to make their way into bonds, even if it isn't low-yielding government debt. January 2013 was the second best January on record for the issuance of U.S. high-grade debt, with $111.725 billion issued during the month, according to International Finance Review.

Bill Gross, who runs the $285 billion Pimco Total Return Fund, the world's largest bond fund, commented on Twitter on Thursday that "January flows at Pimco show few signs of bond/stock rotation," adding that cash and money markets may be the source of inflows into stocks.

Indeed, the evidence suggests some of the money that went into stock funds in January came from money markets after a period in December when investors, worried about the budget uncertainty in Washington, started parking money in late 2012.

Data from iMoneyNet shows investors placed $123 billion in money market funds in the last two months of the year. In two weeks in January investors withdrew $31.45 billion of that, the most since March 2012. But later in the month money actually started flowing back.

Source: http://www.nbcnews.com/business/wall-street-fairy-tale-bull-market-may-hit-snag-1B8219524

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ThreeUK pledges to add LTE to its unlimited data plans at no extra cost

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The old beer-selling adage that good things come to those who wait also applies to those who've yet to sign away a kidney for one of EE's LTE plans. ThreeUK is announcing that it's going to bundle LTE into its existing unlimited mobile data packages without any additional charges. The network is planning to launch its own 4G product later in the year, using spectrum it snagged when T-Mobile and Orange were forced to sell of a chunk in order to see their marriage go through. As such, existing ThreeUK customers who own an LTE-ready device can expect to see their mobile internet shoot through the roof as soon as the capacity is switched on.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/7M9_bstLP7I/

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